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"Sal-FreeTM" means an ingredient or product does not contain any salicylates. It is a reserved term. * A trademark of Guai-Support.
Warning:
Read
About Salicylates
before purchasing products NOT listed in these data bases.
Information & Assistance The Sal-FreeTM pages also contain Sal-Neg products
Salicylic acid is an organic acid with a ring structure, and a salicylate is a salt or covalent compound formed by displacing hydrogen from salicylic acid. It is thought that most, if not all, plants make salicylates as a defence. They are stored in the bark (also contain glycosides which are converted by the liver and intestinal tract to other more potent and long-lasting salicylates), leaves, roots, skin and seeds and act as preservatives to delay rotting. They fend off soil bacteria and pests (reference "Science" [VOL. 266 e November 18, 1994 issue]).
Salicylates (pronounced sah-LISS-a-late) block guaifenesin treatment for FMS at the kidney level. Several studies have been undertaken to try to measure the salicylate content of foods. There is no consensus among the various studies, although certain generalities appear to be true. Salicylates are a family of plant chemicals found naturally in in various chemical combinations in foods such as almonds, apples and cider (including cider vinegar), apricots, berries (all), cherries Chili powder, cloves, cucumbers, grapes (raisins, wine and wine vinegar), nectarines, oranges, peaches, peppers (bell & chili), plums, prunes, tangerines, and tomatoes, in aspirin and other drugs, as well as many cosmetics and personal care products. They are also present in flavourings (e.g. peppermint), perfumes, scented toiletries, eucalyptus oils and some medications (aspirin is a member of the salicylate family). All foods containing salicylates can be 'eaten' as they are somewhat destroyed by the digestive process and further altered by the liver, however, they may very likely block if they manage to bypass the digestive process and liver, thus be very wary of those food & drink sources claiming healing properties. Salicylate Levels in mg per 100 g Food and per Portion. Swain et al
Two Categories of *Natural* Salicylates Guai'ers Need to Avoid
- ingested from herbal medications which are potent enough to easily block guaifenesin (click here for other 'possibilities' in blocking via some food/drink) - topically applied products which deliver salicylates directly into the bloodstream
Food (apart from the 'possible' exceptions listed at the link above) is only an issue where an allergy or sensitivity to salicylates is present (see Salicylate Sensitivity below).
Salicylates are not inherently manufactured by all plants but, in order to protect Guai'ers from the possibility of blocking, our listing is created to take into account their potential to do so. We err on the side of caution.
Salicylates Ingested from Herbals, Vitamins, Supplements & Drugs
In topicals, however, these same plant foods are absorbed directly into the bloodstream and go to the kidneys where they will block. Although most people will block to some degree with any salicylate, blocking sensitivity is a very individual thing. One may block partially where another may block fully. It's very difficult to discern one's blocking potential with any salicylate so it is better to be very rigorous about avoiding salicylates. Some people will take more risk after they experience quite a bit of recovery but it is always best to do the blocking tests and also keep a very close eye on your progress.
In
herbal products
the salicylates are generally in concentrations too high to be processed by the
liver so they get to the kidneys and will block guai for all but a few guai'ers.
The same can apply to any
salicylate extracts in vitamins & supplements. Salicylate fillers, flavors & colours in oral medications/drugs (tablets/capsules) are almost always ok (Sal-neg*) and, as a general rule, will not block the guaifenesin treatment. The amount of salicylate fillers in them is miniscule and considered like foodstuffs. However, we've had a number of very credible blockings reports with Spironolactone/Aldactone (see archives). They were related to the very strong peppermint flavor used to mask the strong odour of its ingredients. The source of the flavor used was not listed. This causes us concern so we consider it prudent, even in oral meds, that you ensure there is not a lot of the most potent salicylates present.
Salicylate fillers, flavors,
colours &
sweeteners, etc., in
topical, lozenge/troche,
sublingual
or oral & nasal spray medications & supplements will block many guai'ers.
The point of these products is to by-pass the
digestive system and to enhance absorption. Especially look out for
any with mint/wintergreen/peppermint but even orange, cherry, Stevia, etc., might block
some Sal-Sensitives.
A
little oil in a supplement is thought to be ok as it is just like eating it
on a salad. The crux of the issue is how much oil and how many
capsules one takes at a time. Mint and Aloe are the two most potent blocking salicylates.
In a few cases chemical ingredients may be impure due to
contamination.
List of ingredients in medications (USA)
The supplement market is not well regulated so it is possible that some products may not contain pure chemicals, even though the label might state it (e.g. Malic acid extracted from apples). One should investigate these products if they feel they are not progressing.
Note: I've been told that in Australia the TGA rule ensures that all herbal products MUST contain various extracts from the plant rather than just a single chemical so this makes supplements containing plants problematic for Aussies. I've had conflicting information regarding this however so please check for yourself and if you get a different answer, please e-mail me.
It is wise to be circumspect regarding how many
Low-Sal* items you use in the course of a day
and, as some of us are more sensitive to salicylates than others, it is strongly recommended to avoid all of them until such time as you are well enough to detect a difference in reversal when using a product which may
include some.
New OTC (over the counter) drug
labeling rules: The regulations for labeling of OTC drug products are found in 21 CFR 201.66. Click here to access the CFR online. From there, choose Part 200-299, then Part 201, then 201.66. Click here for the OTC drug product labeling requirements. Click here for this second link which provides for the partial delay of compliance dates for "convenience size" products. Click here for the publicly available web site that contains information that you may find useful: Leah A. Christl, Ph.D. Rules for Defining Salicylates
If the ingredient is a chemical, no matter the origin, it is okay, except:
A number in combination with a chemical word
is ALMOST always okay
(it represents the position of certain atoms in the structural formula of the
compound).
The only exceptions noted at this time
are included in the lists of synonyms below. NOTE: There is no such thing as "plain" methyl hydroxybenzoate; the structure of this can be arranged in a variety of ways, called "structural isomers". There are usually clues in their names to tell you what you need to know to determine which particular "form" that this particular ingredient takes; it is to do with the arrangement of the hydroxy (OH) group and the carboxyl (COOH) group in relation to each other, as they are attached to the benzene ring. The salicylate structure is the one where the hydroxy and carboxyl groups are adjacent, ie attached to carbon atoms in the benzene ring that are next to each other. This can also be called "orthogonal", or shortened to "ortho" or simply "o" in the name, or the number "2" may be used to indicate the position. Examples of these are methyl 2-hydroxybenzoate or methyl o-hydroxybenzoate. The alternative structures, which are not salicylates are the "para" (short for parallel) and "meta". "Para" or "p" forms have the two groups opposite each other across the benzene ring, and may have the number "4" in their name. The "meta" or "m" form is where the two groups have one carbon between them in the benzene ring, and may have the number "3" in the name. Examples of these are methyl 4-hydroxybenzoate or methyl para-hydroxy benzoate, and methyl 3-hydroxybenzoate or methyl m-hydroxybenzoate. If the name is ambiguous (for example, simply "methyl hydroxybenzoate"), the manufacturer should be able to tell you which form it is. But if they can't, I wouldn't use the product. The same applies to 'Propyl Hydroxybenzoate'. Many chemicals are listed as, or contain, acronyms as part of their name (e.g. Azelastine HCL, Capramide DEA) but all acronyms should be checked to be sure.
Just because you can find a chemical structure does not, in and of itself, indicate if the chemical is not a member of the salicylate family. A unique chemical structure does mean that the ingredient in question is only one chemical, and not a composite of several chemicals. There is a specific molecular structure that occurs in all salicylate chemicals. If you want to learn what a sal looks like, take a look at the chemical structure for salicylic acid. The benzene ring, the "Y" with the double line going out to an "O", and a single line to an "O" on the other side of the "Y", and an "O" on an adjacent point are the distinguishing characteristics of salicylates. Take a look at some other known chemical sals and identify the sal pattern within the total chemical structure. Good examples are common ingredients in sunscreens homosalate and Octyl salicylate. Note that if you cannot find a chemical structure, it typically indicates that the ingredient is a combination of chemicals, some of which might be sals. Vegetable, seed, and nut oils are a good example of this.
Any entry listed on the Sal-FreeTM Ingredient list is also fine when two or more of them are listed together as a single entry.
A number in combination with a chemical word
is ALMOST always okay
(it represents the position of certain atoms in the structural formula of the
compound).
The only exceptions noted at this time
are included below in the lists of synonyms. The following chemical names can be found in credible chemical databases. These are just a few FYI: National Library of Medicine; Chemfinder.com; National Institute of Standards and Technology
It can be confusing to know
exactly where one name finishes and another begins thus it helps to know that
all the names below are separated by a semi-colon (;)
Synonyms
of Salicylic Acid:
Synonyms for
Octyl salicylate:
Benzoic acid, o-hydroxy-, octyl
ester; N-Octyl o-hydroxybenzoate.
Synonyms for
3-Aminosalicylic acid:
Synonyms for Ethyl Salicylate: Ethyl o-Hydroxybenzoate; Sal ethyl; Salicylic ether.
Synonyms for Benzyl Salicylate: 2-Hydroxybenzoic acid phenylmethyl ester; Benzoic acid, 2-hydroxy-, phenyl methyl ester; benzyl o-hydroxybenzoate; SALICILATO DE BENCILO; Salicylic acid benzyl ester.
Synonyms for 4-Nitrophenyl salicylate: Salicylic acid 4-nitrophenyl ester.
Synonyms for Amyl salicylate: Salicilato de amilo.
Synonyms for n-Butyl Salicylate: 2-hydroxy-benzoic acid, butyl ester; Benzoic acid, 2-hydroxy-, butyl ester; Butyl salicylate; Salicylic acid n-butyl ester.
Synonyms for Methyl 2-methoxybenzoate: Dimethyl salicylate; Methyl o-anisate; Methyl 2-methoxybenzoate; Methyl salicylate o-methyl ether.
Synonyms for Methyl 4-methoxysalicylate: Methyl 2-hydroxy-4-methoxybenzoate.
Synonyms for 2-Ethylhexyl salicylate: Sunarome O; Sunarome WMO.
Derivatives of salicin:
salicortin, tremulacin
Controversial
Items
Identified as free from salicylates by others but which we find questionable or disagree: Corn oil; wheat germ oil; Shea Butter; Spironolactone/Aldactone
Menthol; Mentholatum; Propolis; Bioflavonoids (sometimes spelled bioflaviniod) Grapefruit Seed Extract Inulin (like everything else, if it is a purified extract, it is fine because inulin itself is a salicylate free single chemical compound)
NEW June
22, 2007:
FDA Issues Dietary Supplements Final Rule Sal-FreeTM ingredients might be contaminated with
salicylates during production,
i.e. in theory, chemical extractions, including
Click here to see items listed in unsure category.
Some non-sensitive Guai'ers actually want to experiment with the odd product containing controversial ingredients, usually (but not necessarily) short term, in order to address a specific health issue, generally broaden their options, or to make their lives a little less restricted. Our goal is to list the status of ingredients correctly (not allowing contamination to impinge on the chemical compound status), putting the power in the user's hands and enabling informed decision-making. If we have specific information related to contamination that will be listed also. Keep in mind that any OTC product, where it is not specifically stated that it is pharmocologically pure, may be contaminated from the source, which in turn MAY contain salicylates. Salicylates are made in all plants to fend off soil bacteria and pests (reference "Science" [VOL. 266 e November 18, 1994 issue]).
Please read all the information re: salicylates in the Sal-FAQ and other documents on this site.
If Members of the Guai-Support mailing list are unsure about a product they can send a list of the ingredients (both active and inactive) which are NOT already listed on either the Sal-FreeTM or Sal-Full*, to the SAL Topic on the list and we'll do our best to let you know if they are salicylates. When you ask questions of labs or cosmetic companies, be sure to obtain a complete ingredient list as it is the only way to be sure of a product's sal status. If you decide to mention salicylates, you need to clarify that it is both "natural and synthetic salicylates" you are asking about and make sure they understand that the theory we operate under is that all plants inherently contain salicylates or they make them to fend off soil bacteria and pests (The reference that all plants make salicylates is: "Science" (VOL. 266 e November 18, 1994 issue).
Although one can make some rules about what is or is not a salicylate there are dangers in making those rules too simple, e.g. most ingredients with a number as part of their names are chemicals but there are exceptions so any rule must also note those exceptions.
Many of us have similar blocking potential so it is a good place to start when thinking about what might block you, however also remember that some are more sensitive to salicylates than other Guai'ers so please don't assume that a product which doesn't block someone else won't block you. If you feel you must use some particular supplement and yet don't progress in your guai treatment please do a blocking test and be very careful how many low-salTM products you use in your daily regimen. We have no idea how many Low-SalTM products each person can use or if there might be a level in which blocking will start to occur. A blocking test doesn't typically help detect partial blocking. Put Low-SalTM items away for a few weeks and see if you notice a discernible difference.
Note: Blocking 'can' be a very subjective experience.
Sometimes members report blocking because of various experiences which may or
may not have been related to what every guai'er might consider
adequate testing procedures.
Guai'ers Need to Check These Items Carefully for Salicylates
Everything that goes on your skin or in your mouth.
Any "medicated" product may contain unlisted ingredients including added salicylates.
If something feels "cool" or "burns' when applied check it out with the company
if nothing that would account for it is
listed. Check the label for Xylitol because that is ok and may explain the
coolness. Check any product that claims to have a healing benefit.
Acne products and wart removers are often pure salicylates.
Lipsticks & Lip Balms for aloe, camphor, castor oil, mints, wintergreen,
etc. Also check out
Piperitone.
Medications
Panty Shields for Aloe (some companies have
begun adding it)
Razors (strips beside the cutting edge)
Shaving Creams often contain aloe & ingredient lists can't be trusted. From what we know at this point we don't think any company can guarantee that razor strips or shave creams are ever totally free of aloe. Given that it is such a potent salicylate, and shaving provides such a good entrance for sals, we are inclined to warn that we can't trust these labels, and we are worried about contamination of apparently *Sal-Free products. One can use a Sal-FreeTM lotion or hair conditioner as a shave cream.)
Shampoos
Tissues (facial/toilet) for lotions,
i.e., aloe vera, Eucalyptus oil, etc.
Toners For Witch Hazel.
(calling companies may not bring full disclosure in the case of toothpaste and hidden sals are often added to toothpaste, so it is best to stick with those specifically listed on
the sal-free list.)
Topical cortisone creams may contain aloe
(The way Ben Gay works is the same way that Aspergum works, by delivering aspirin directly to the painful area. Studies have shown that these salicylates travel throughout the body rapidly.
Many topicals fall into two categories of salicylates; they either contain
Menthol, Eucalyptus, Aloe and the like or they contain aspirin.
A compounding pharmacist can mix one up for you specially with a prescription. Be careful though, the cost of a small container of compounded cream can be very expensive and check that your insurance will pay for it.
Ultrasound Gels often contain sal's (Aloe)
Wart or callus removers
FOOD INTOLERANCE NETWORK FACTSHEET:
"Food allergy is an immunological reaction to
food proteins. Food intolerance is a pharmacological reaction (like the
side effects of a drug) to the chemicals in foods. "
Salicylate Sensitivity is
an area of concern for many people. A sensitivity can show itself when
individuals find themselves unable to tolerate certain fruits, vegetables &
medications containing aspirin.
"Some individuals feel that
they have a salicylate intolerance or allergy that causes them serious health
problems. Some have reported a wide range of symptoms that they feel are
alleviated by strict avoidance of salicylates in food and other products."
(WSE)
"Salicylates directly or indirectly affect
most organ systems in the body by uncoupling oxidative phosphorylation,
inhibiting Krebs cycle enzymes, and inhibiting amino acid synthesis."
(WSE)
Salicylate is listed as a drug that may be related to hypoglycemia and Reactive
Hypoglycemia.
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