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Guaifenesin Sources
Guaifenesin is pronounced 'gwy-fen-e-sin' - the "e" between "fen" and "sin" should be pronounced like the "e" in "item". On GG it is known affectionately as guai ('gwy') and those following the Guaifenesin protocol, are called Guais (i.e., Gwys), a little play on the word 'guy'.
Contents: (LA - QA - Q+LA & Synonyms, measurements of powder, cream + 'Action of LA caps') Guaicum (treatment for syphilis-Lyme)
Splitting Capsules & Tablets
Guaifenesin - Summary of Interactions with Vitamins, Herbs, and Foods October 17, 2003:
FDA Proposes Steps to Assure the Safety and Efficacy of Certain Currently
Unapproved Medicines
ALL Guaifenesin
is appropriately manufactured A: This is one of those queries that come up from time to time, seemingly based on past concerns when answers were being sought to the failure of some guai’ers to progress, as expected, on LA products. GG research indicated that the reason for this was most likely ‘people respond differently because they are different people’ and opinion provided by pharmacists, at that time, did not support the notion that Asian ‘raw’ product was the problem. More recently, an Australian compounding pharmacist responded: "Thank you for the opportunity of
commenting on guaifenesin. I would say that we must distinguish between the
active ingredient (i.e., Guai raw material ) and the finished product (capsules
and tablets). This is because most of the Guai active comes out of Asia,
principally Taiwan and China and we have no real knowledge of their quality
control. For that reason, I would have to say that it is better if the Guai
finished product comes out of the USA, Australia or another country where the
manufacturers of the capsules or tablets have met the stringent requirements
of the
FDA*, the TGA, or
equivalent governing body, no matter what the source of the raw material. This
requires that the manufacturer meets those requirements like auditing the
suppliers of the active ingredient, no matter what its source, test it for
potency and purity and manufacture the finished dose from within an
appropriately licensed and inspected facility. This, of course, means finished
product testing and greater assurance in product quality for the consumer."
Antony Accordino All legally
manufactured single-ingredient guaifenesin, whether immediate-release or
extended-release, is FDA-approved. No approval has a higher status than another,
with regards to guaifenesin (Gregory
K. Penniston, D.C., Pg, 62,
The Guaifenesin Guide
-
Out of Print. Please see the new
edition titled,
Fibromyalgia, Chronic Fatigue & Irritable Bowel: Treating Symptoms Treating
Cause By Gregory K. Penniston, D.C.
In this book Dr. Penniston explains how and why the different
treatments that are commonly used can be of help. He also explains that these
treatments are limited because they do not treat the underlying cause of these
conditions. The little known medication, guaifenesin, does appear to treat the
underlying cause in many people. Dr. Penniston explains why guaifenesin works
and how to best use it. Acceptable Guaifenesin Compounds
Long-acting = LA (Pharmaceutical terms: ER = extended-release, SR = sustained-release)
Quick-acting = QA (Pharmaceutical terms: RR = regular-release, IM = Immediate-release)
Quick-acting/Long-acting
Combination = Q+LA Long-acting Compounded Capsules = LACC
Quick-acting Compounded Capsules = QACC
Quick- acting Compounded Topical Cream = QACTC
Quick-acting Home-made Topical Lotion = QAHMTL (Click here to see Rowena's recipe) Measuring out & dosing topical guai: There have been reports that the responses differ between types of guai taken, e.g., less topical (QA) guai is needed to invoke the same response as a QA tablet and less encapsulated QA guai is needed to invoke the same response as a QA tablet. There is no way to calculate an "equivalent" dose when switching from tablets/capsules that are swallowed, to a topical preparation. You will need to start again from the beginning, with a low dose and slowly increasing until you reach a point where you think it's having an effect. When you order your topical guai from a compounding pharmacist, ask she/he if s/he would prepare it in a hypodermic syringe MINUS the needle. The plastic tube has measuring marks on it. The dosage marks are easy to read and the plunger just has to be moved carefully to expel your dose X 2 daily. A small cap covers the place where the needle would be and where the cream comes out when you squeeze the plunger. If for some reason your pharmacist won't do it (although I'd be surprised), you have already purchased your cream or you are making it at home you can purchase the syringes and insert the cream yourself.
Work out something that is convenient to you, and stick
with it. Maybe squeezing out 1mm, or 5mm or whatever, of gel onto your
finger will be something you can cope with - you could do it over a ruler
for greater accuracy. Don't concern yourself with calculating just how much
guai is in the portion you squeeze out of the tube and apply to your body,
but do watch that you are consistent with how much you use on each step of
the titration process. "The
anatomy of the digestive system LA or QA Guai: Which Kind is Right for Me? ------------****----------- Gel capsules sizes: #0 = 300mg -- #00 = 600mg 1) Pure Guaifenesin LA or QA
capsules of any strength LA, QA or Q+LA 3) Pediatric sprinkles are no longer in production. To work around this, use pure powder and mix with jelly/jam as guai is very bitter. 1/8 tsp = 300mg; 1/4 tsp = 600mg 4) Sugar and alcohol free
Liquids (pack or have packed for you (can be compounded to LA or left QA) 7) Topical Guaifenesin (a recent innovation) Tom Slaughter of Mulberry Compounding Pharmacy assures us that guaifenesin is absorbed through the skin. Several people are known to be using it and all of them are cycling on it at a dose lower than their previous long-acting dose. There may be other compounding pharmacies in your own area willing to order Guai powder and make up capsules or topical cream for you. One member makes her own. 8) Compounded Guai (Be sure to state on the prescription the reason you need especially compounded Guai, e.g. sensitivity to dye, you need to split your dosage and Mucinex is difficult to break, etc.)
Note: Glyceryl Guaiacolate
[93-14-1] Synonyms: guaifenesin;
Actifed; Allerid; Cenafed; Decofed; Drixoral; Novafed; Sudafed; Trinalin;
Azatadine; Optimine; D-threo-2-(Methylamino)-1-phenylpropan-1-ol; Guaiacol
glyceryl ether; Guaiphenesin; Deconsal II; Dimacol; Actifed-C; Myocaine; Contac
Cough Formula; Relaxil G; Sirotol; Brexin EX; Cremacoat 2; Aeronesin; Amonidrin;
Congestac; alpha-Glyceryl guaiacol ether; AI3-24947; Aresol; Calmipan; My 301;
Guaiacyl glyceryl ether; Glyceryl guaiacyl ether; XL-90; Colrex Expectorant;
Equicol; Gecolate; Glycodex; Oresol; Neuroton; Robitussin;
3-(2-methoxyphenoxy)-1,2-propanediol; 3-(2-Methoxyphenoxy)-1,2-propanediol,
threo + erythro;
Calcium binds to phosphate as calcium phosphate and, added to meals (Tums, etc.) may be carried out of the body via increased fecal elimination. This may also allow for lower doses of guaifenesin and one could experiment if so inclined.
The Guaifenesin (eexpectorant) protocol we follow & discuss uses a synthetic chemical compound.
Guaifenesin is an expectorant, which loosens and thins mucous, not a decongestant. Decongestants can raise BP and require great caution if used with history of elevated blood pressure (labels may indicate this). According to the literature, there is no need to be concerned about guaifenesin raising BP.
Do not take Guaifenesin in combination with something else such as Dextramethorphan (cough suppressant [e.g. Mucofen], [further reading], or Pseudoephedrine (decongestant) unless specifically & knowingly RX'd by your doctor for a condition other than FMS. If it's necessary to take Liquid Guaifenesin for a particular reason appropriate ones are listed below.
Do not use Entex LA unless
specifically RX'd by your doctor
for reasons other than FMS. It is not pure guai.
It contains
Phenylephrine as the
decongestant. ( It used to contain
75 mg. of Phenylpropanolamine Hydrochloride, which is a
decongestant that can raise blood pressure, and only about 200 mg
of guai.) We have no information on how people do on Guaiacum homeopathic Guaifenesin (Botanical: Guaiacum officinale (LINN.) Family: N.O. Zygophyllaceae), nor the Guaiacum Wood, but they are listed here for those interested in investigating and/or experimenting with them. More on Guaiacum officinale.
Guaifenesin has a short half-life, which is why
it is recommended that we take it in divided doses instead
of just once every 24 hours.
If you purchase guaifenesin LA (long-acting) and wish to keep it that way don't crush or chew tablets as it interferes with the long acting capability. You can & should do all the above if you wish to make your LA Guai QA (quick-acting). For more information regarding products please click here. There is no scored LA on the market at the time of this writing (05/02/14)
The uricosuric action of guaifenesin was found many years ago however it is not common knowledge, and there is no label warning on any guai product, that Guaifenesin has the ability to alter uric acid test results which may cause problems for those with gout.
Guaifenesin can falsely elevate the results of laboratory tests for vanillylmandelic acid (VMA), which is the main urinary metabolite of catecholamines (adrenaline and noradrenaline). In addition, it is well known that guaifenesin can cause false positive results in tests for the serotonin metabolite, 5-hydroxyindoleacetic acid . You should stop taking guaifenesin 48 hours before giving urine for either of these tests.
(By the way, aspirin also interferes with VMA and 5-HIAA tests. Ephedrine and caffeine cause increased values in 5-HIAA tests. Foods that are high in serotonin (avocados, bananas, eggplant, pineapples, plums, and tomatoes) can also cause false positives in 5-HIAA tests. An awful lot of foods and even artificial coloring and flavoring can cause false positives on a VMA test.)
Guaicum: Treatment for Symphilis (borellia, a spirochete - the bacteria that causes Lyme) Guaicum Treatment for Syphilis Syphilis is a special type of bacteria that is similar to borellia (the bacteria that causes Lyme) in that it is a spirochete. Given the connection in symptoms between lyme and fibromyalgia, it is very interesting that guaicum was considered a treatment for syphilis. Aside from the connection in symptoms, this also seems to point to the possibility that those with fibromyalgia may have a spirochetal infection which may be why guai is effective for some people. New spirochetes are still being discovered. There were originally no effective treatments for syphilis. The most common in use were guaiacum and mercury: the use of mercury gave rise to the saying "A night in the arms of Venus leads to a lifetime on Mercury". Though no proper studies were done to prove it, mercury may have been an effective means to treat syphilis.
If
you notice a change with a medication, contact the manufacturer (compounding
pharmacy or pharmaceutical company) immediately and then follow up with your
doctor if the medication is found to be remiss in any way. An unexplained change
of any kind (e.g., color change, swelling or a different smell) could indicate
that the product has undergone some sort of chemical reaction. This can happen
from heat or moisture and, although it is wihin the the correct date, the above
changes may have caused expiration.
Storing
Guaifenesin
Heat and/or humidity can affect the efficacy of
medications so store your
guai properly, and buy from sellers you trust to do the same.
Dolores' sent this storage tip: A gardening show host, who was giving tips on how to store seeds over the winter, took 2 teaspoons of powdered milk, put them in a double sheet of paper towel, put them at the bottom of a plastic container, put the seeds in, put the lid on and then stored the container in a cool dry place. Apparently there is something in the powdered milk that draws all the moisture out. Splitting Capsules and Tablets Into Smaller Strengths
Guaifenesin Manufacturers/Brands
All previous LA are now unavailable (since November 2003) until the manufacturer seeks an NDA or ANDA. All QA (quick-acting, regular-release) continues to be available over-the-counter, although not many are available in local drugstores/chemist shops. Look to Compounding Pharmacists if you require long-acting Guaifenesin other than those listed below. Compounding pharmacists have separate rules than mass producers so guaifenesin can still be compounded in any requested formats/doses.
Much discussion has taken place regarding the efficacy of the products listed below. You will find those discussions in the GG archives. Allfen Jr. 400 QA US GG Member informs us that this has now been discontinued (October 10, 2005) Expectorant/Expectorant NDC# 58605-530-01 400mg Immediate Release Guaifenesin. Click here for all the information we have on this product. (Not the Allfen Expectorant/Expectorant NDC# 58605-613-01 150mg Potassium Guaiacolsulfonate 1000mg Guaifenesin as we don't know how safe it is for long term use. Talk to your doctors) Bidex 400 mg, QA (quick-acting, an immediate-release guaifenesin) Marketed by Stewart-Jackson Pharmacal, Inc. and MCR American Pharmaceuticals. It is available by prescription in the southeast part of the US and covered by some insurance policies (It is apparently appropriate for us; apart from price!) Fenesin IR (Immediate-release) 400 mg
Fludan
(Pure Guaifenesin Powder, Ready made 300mg & 600mg capsules,
encapsulated mg amount to your preference, empty Capsules & capsules packer
& Guaiacum) Guai-Aid Caplets and Capsules in various strengths Guai-Care QA or LA. ANY strength caps & Topical Guai cream Mulberry Compounding Pharmacy GuaiLife 200 mg & 400 mg QA (quick-acting) tablets (Dr. Gregory Penniston) Humibid E 400mg QA - NEW - (October 1, 2004). [NOT the CS which contains Dextromethorphan] It is manufactured & packaged by PharmaFab, using the same guaifenesin source & granulation process used in their previous RX products. (This product is no longer being sold by Cornerstone Biopharma due to a deal between Cornerstone and Adams labs. We at GG suggest that if you like this product you stock up on it in case the 'worst' occurs and Adams remove it from the market to bolster sales of Mucinex. Please click here for more information (GG archives, March 16, 2005) Currently it is available on-line and at local stores [50 or 100 tab bottles] in the US, including K-mart.
Liquibid 600 Mg
- ION Pharmaceuticals (No info on this) Mucinex Q+LA -- Adam's Labs (OTC newly patented dual action tablet includes a fast acting layer (200 mg) for rapid onset of action and a long lasting layer (400 mg) continues effect for a full 12 hours.) (Pro Health LA are Mucinex) Mucus Relief Guaifenesin, QA (Immediate-release) tablet - 400 mg x 30 tablets. Inactive Ingredients: Magnesium Stearate , Maltodextrin , Microcrystalline Cellulose , Povidone , Silicon Dioxide , Sodium Starch Glycolate , Stearic AcidNaldecon Senior EX (OTC) Each teaspoonful is 200 mg. It is sugar and alcohol free but does contain Saccharin.
International Shipping URL (United Research Labs) x 200 mg QA Mutual Pharmaceutical Co., Inc. -- Dr. Richard Roberts, 1100 Orthodox Street, Philadelphia, PA 19124
Interesting
History of Guai
Guaifenesin Retail Sources
Australia
Dartnell's Pharmacy (compounding)
New South Wales
Bankstown 2200
Quoc Nguyen
Edgecliff, Sydney
Compounding Pharmacist
Dr Lily Vanker
is on our guai doctor list (Edgecliff). West Lindfield (North Shore) Sydney West Lindfield Pharmacy They make it for Dr Schloeffel's patients. Ph: 02 9416 2642.
Also see Recommended Guai doctors: phone consultation with OZ Doc (Richard Schloeffel) . He dispenses Guaifenesin with consultations. (My information is that he's very expensive and has a long waiting list.)
South Australia
Erindale Compounding The Green Dispensary
The Green Dispensary
Queensland
Gold Coast 457 Golden Four Drive Phone. (07) 5534 2327
Canada Guai Availability UPDATE:
Latest update from Fludan Fine
Chemicals, July 2003:
"We were told by health canada that a DIN
would be one way to continue, but as we research it - it turns out to be a
very expensive and almost an impossible route. It had sounded great at the
time but little was explained to us about the procedures. So for now we are
grateful Dr. Ceaser has decided to help us in this matter as we can only sell
to pharmacies or Doctors. Luckily he has been following the protocol for
about 3 yrs and knows it works. If ever we are again able
to sell directly to the public we will announce it on all the sites. Thanks
again.
Smith's Pharmacy
TLC Pharmacy Edmonton, Alberta Canada T5T 5W8 (ship guai all over the world) (780) 444-4022 FAX (780) 483-0825 http://www.tlcpharmacy.com/cyberpharmacist.html Email Addresses: TLC Pharmacy tlcpharmacy@tlcpharmacy.com Ron Marcinkoski ronmarcinkoski@tlcpharmacy.com The CyberPharmacist cyberpharmacist@tlcpharmacy.com
It is in powder form and they put it in whatever size capsules you want. The cost for 100x300gr is about $25 CDN ($10 for putting it in capsules) and that includes shipping. Check with your own authorities regarding importation of drugs into your country. FLUDAN
Fine Chemicals, Inc.,: Pure Guaifenesin Powder
& encapsulated (QA)
They also sell empty capsules and capsule packers. Guaiacum Wood: $CAD10.00 X 500g -- $CAD17.50 X 1kg. Web: http://www.fludan.com/
1 Tablespoon (7200mg) will fill
24 X 300mg gel capsules
Since pediatric sprinkles are no longer available a work around is to mix Fludan powder with jelly/jam (guai is very bitter). WILER Fine Chemicals Powder Guaifenesin (higher cost than Fludan).
Medisca Pharmaceutique Inc: from Medisca Montreal, Quebec, Canada -- $51.99 800-665-6334 or 514 333-7911.
NutriChem Pharmacy
compounding lab: Contact your pharmacist, who has catalogues of products from various manufacturers, and ask him/her to order the pure guaifenesin powder for you.
The pharmacist can help you figure out how much guai powder to put in a gelatincapsule to make various doses. There is info in the archives about ways to fill the capsules.
Gel capsules can be found in some health food stores, and cost varies.
Europe Subject: Guai
United States of
America
Guaifenesin FA (400 mg, 100 oblong tablets)
Reformulated to contain natural vanilla
flavour and stevia. Please retitrate if progress is slowed or stalled.
Mucinex Expectorant, Guaifenesin Extended-Release 600 mg Tablets - 20 ea
Mucinex (Guaifenesin, 600mg) (600 mg, 40 tablets)
Mucinex-Extended Release Mucus Expectorant, 60ct
Mucinex
Guaifenesin Extended-Release 600mg Tablets, 100 Tablets
Guaifenesin 600 (600 mg, 100 tablets)
Mucinex Expectorant, Bi-Layer Tablets, 500 tablets
Guaifenesin USP bulk (powder) (500grams) SALE Brand: Fludan
for more Information related to cutting tablets.
Bellevue Pharmacy Solutions
Bemis Drug MA., 02351. Call 1-781-878-0893 and ask for BILL. Cape Apothecary / Cape Drugs
Clark's Drugstore Costco Their member services number is: 1-800-774-2678. You could find out where the closest one is, and what their price is for guai. District Drugs &
Compounding
Center
(Pharmacy) "Fibro GMM" cream (for guaifenesin,
magnesium, and malic acid). You can buy on-line at
drugstore.com while purchasing other Sal-FreeTM products GuaiCare QA - LA - Compounded guaifenesin
Topical Finally, many patients using the guaifenesin protocol may dislike the many “ups and downs” associated with phosphate cycling. A topical gel allows them to dose themselves in small increments throughout the day to avoid the hard painful cycling associated with oral tablets." GG: Thus, if you have 100mg of cream, and it contains 10% guai, then there would be 10mg guai in that 100mg of the cream. Health Products Express, Inc. Free Shipping on all U.S. Orders Over $149.00
Hydrex Pharmaceuticals: It's pure Guai. No RX needed. Kaiser Fenesin IR (Immediate-release) 400 mg
Lomed Labs: The Medicine Shoppe Medi-Mail: Phone:800-422-6579 Rider Pharmacy Guaifenesin compounding for FM Date: 97-11-12 19:20:48 EST From: RiderPhcy To: KShuller We are certainly interested in providing the Guaifenesin to your members. At this point in time , there does not seem to be a problem obtaining the materials necessary to compound the product. The capsules would be compounded here at our pharmacy. Please contact Dan or Jerry at 1-800-207-1824 to discuss details. Thank you for your interest in our professional services.
RxMPSS/ MedsBUYMail
If you have any questions please contact Essential Pharmacy Compounding by phone at: 1-888-733-0300 or 1-402-408-0016. Your physician can fax a prescription order to 1-402-408-0020. 500 x 600 mg LA capsules = $125.00 plus S&H 1000 x 600 mg LA capsules = $ $200 plus S&H. Click here for web site: The Medicine Shoppe
(Compounding) Total Healthcare Pharmacy
RxPalace.com No prescription needed. Walgreen brand of 400mg QA Humibid LA 600-300mg, 12 Hour Tablets Ye Olde Pharmacy Pure Powdered Guaifenesin 5320 N. Port Washington Rd., Glendale WI 53217, Milwaukee. (414) 963-0811. Zenith Goldline,
Manufacturer
Previously Listed Brands
Prior to November 2003.
Fludan (Pure Guaifenesin Powder, Capsules & capsule packer)
Removed April, 2004
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